Stress urinary incontinence animal models as a tool to study cell-based regenerative therapies targeting the urethral sphincter

Abstract

Urinary incontinence (UI) is a major health problem causing a significant social and economic impact affecting more than 200million people (women and men) worldwide. Over the past few years researchers have been investigating cell therapy as a promising approach for the treatment of stress urinary incontinence (SUI) since such an approach may improve the function of a weakened sphincter. Currently, a diverse collection of SUI animal models is available. We describe the features of the different models of SUI/urethral dysfunction and the pros and cons of these animal models in regard to cell therapy applications. We also discuss different cell therapy approaches and cell types tested in preclinical animal models. Finally, we propose new research approaches and perspectives to ensure the use of cellular therapy becomes a real treatment option for SUI.

Keywords: Animal models of urinary incontinence; Cell-based therapy; Mesenchymal stem cells; Muscle regeneration; Stress urinary incontinence; Urethral dysfunction; Urethral sphincter.