Nanoencapsulated and microencapsulated SERS platforms for biomedical analysis

Inna Y Stetciura; Alexey V Markin; Daniil N Bratashov; Gleb B Sukhorukov; Dmitry A Gorin

doi:10.1016/j.coph.2014.10.002

Nanoencapsulated and microencapsulated SERS platforms for biomedical analysis

Curr Opin Pharmacol. 2014 Oct:18:149-58. doi: 10.1016/j.coph.2014.10.002. Epub 2014 Oct 21.

Authors

Inna Y Stetciura¹, Alexey V Markin¹, Daniil N Bratashov¹, Gleb B Sukhorukov², Dmitry A Gorin³

Affiliations

¹ Saratov State University, Astrakhanskaya Street 83, Saratov 410012, Russia.
² School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London E1 4NS, United Kingdom.
³ Saratov State University, Astrakhanskaya Street 83, Saratov 410012, Russia. Electronic address: gorinda@mail.ru.

PMID: 25450069
DOI: 10.1016/j.coph.2014.10.002

Abstract

The problems of layer-by-layer-based surface enhancement Raman scattering (SERS)-sensor application for pharmaceutical analysis were discussed. Layer-by-layer (LbL) method allows fabrication of encapsulated SERS platforms with high reproducibility of enhancement factor and increased signal/noise ratio of Raman scattering. LbL encapsulation approach opens an avenue to implement a novel type of theranostic systems combining SERS based sensing and drug delivery in one entity. The area of encapsulation development toward smart multifunctional theranostic systems could bring benefits for personalized medicine and should minimize costs and resources at preclinical and clinical study in pharmacology while testing new bioactive compounds.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Drug Compounding
Drug Delivery Systems
Humans
Nanostructures / chemistry*
Nanostructures / therapeutic use
Spectrum Analysis, Raman*