Towards broadly protective polyvalent vaccines against hand, foot and mouth disease

Qingwei Liu; Xin Tong; Zhong Huang

doi:10.1016/j.micinf.2014.11.004

Towards broadly protective polyvalent vaccines against hand, foot and mouth disease

Microbes Infect. 2015 Feb;17(2):155-62. doi: 10.1016/j.micinf.2014.11.004. Epub 2014 Nov 29.

Authors

Qingwei Liu¹, Xin Tong², Zhong Huang³

Affiliations

¹ Vaccine Research Center, Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China.
² Shanghai Zerun Biotechnology Co., Ltd., Building 9, 1690 Zhangheng Rd, Zhangjiang, Pudong New District, Shanghai 201203, China.
³ Vaccine Research Center, Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China. Electronic address: huangzhong@ips.ac.cn.

PMID: 25449959
DOI: 10.1016/j.micinf.2014.11.004

Abstract

Hand, foot, and mouth disease (HFMD) caused by multiple enterovirus infections is a serious health threat to children in the Asia-Pacific region. This article reviews progresses in the development of vaccines for HFMD and discusses the need for polyvalent HFMD vaccines for conferring broad-spectrum protection.

Keywords: Coxsackievirus A16; Enterovirus 71; Hand, foot, and mouth disease; Polyvalent vaccine.

Publication types

Review

MeSH terms

Asia
Child, Preschool
Enterovirus A, Human / immunology*
Hand, Foot and Mouth Disease / prevention & control*
Hand, Foot and Mouth Disease / virology
Humans
Infant
Viral Vaccines / immunology
Viral Vaccines / therapeutic use*

Substances

Viral Vaccines