How genomic studies have improved our understanding of the mechanisms of transcriptional regulation by NR5A nuclear receptors

Carmen Ruggiero; Mabrouka Doghman; Enzo Lalli

doi:10.1016/j.mce.2014.10.022

How genomic studies have improved our understanding of the mechanisms of transcriptional regulation by NR5A nuclear receptors

Mol Cell Endocrinol. 2015 Jun 15:408:138-44. doi: 10.1016/j.mce.2014.10.022. Epub 2014 Oct 31.

Authors

Carmen Ruggiero¹, Mabrouka Doghman¹, Enzo Lalli²

Affiliations

¹ Institut de Pharmacologie Moléculaire et Cellulaire CNRS UMR 7275, Sophia Antipolis, Valbonne, France; Laboratoire International Associé (LIA) CNRS NEOGENEX, Sophia Antipolis, Valbonne, France; Université de Nice, Sophia Antipolis, Valbonne, France.
² Institut de Pharmacologie Moléculaire et Cellulaire CNRS UMR 7275, Sophia Antipolis, Valbonne, France; Laboratoire International Associé (LIA) CNRS NEOGENEX, Sophia Antipolis, Valbonne, France; Université de Nice, Sophia Antipolis, Valbonne, France. Electronic address: ninino@ipmc.cnrs.fr.

PMID: 25449416
DOI: 10.1016/j.mce.2014.10.022

Abstract

SF-1 and LRH-1 are transcription factors that belong to the NR5A family of nuclear receptors that both have an essential role during development. Recent studies at the genome-wide scale have enabled the characterization of the cistrome and transcriptome regulated by SF-1 and LRH-1 in different cell lines and tissues. Those studies have allowed us to make a significant leap forward in our understanding of the mechanisms of transcriptional regulation of NR5A nuclear receptors in stem cells and cancer.

Keywords: Adrenal cortex; Endocrine cancers; Nuclear receptors; Transcription factors.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Gene Expression Regulation*
Genomics*
Humans
Models, Genetic
Organ Specificity / genetics
Receptors, Cytoplasmic and Nuclear / metabolism*
Transcription, Genetic*

Substances

Receptors, Cytoplasmic and Nuclear