Abstract
Extra-virgin olive oil (EVOO), a principal component of the Mediterranean diet (Med diet), is one of the most ancient known foods and has long been associated with health benefits. Many phenolic compounds extracted from Olea europea L. have attracted attention since their discovery. Among these phenolic constituents, oleocanthal has recently emerged as a potential therapeutic molecule for different diseases, showing relevant pharmacological properties in various pathogenic processes, including inflammation, cancers and neurodegenerative diseases. Here, we discuss and summarize the most recent pharmacological evidence for the medical relevance of oleocanthal, focusing our attention on its anti-inflammatory and chemotherapeutic roles.
Copyright © 2014 Elsevier Ltd. All rights reserved.
MeSH terms
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Aldehydes / history
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Aldehydes / isolation & purification
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Aldehydes / therapeutic use*
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Animals
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Anti-Inflammatory Agents / history
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Anti-Inflammatory Agents / isolation & purification
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Anti-Inflammatory Agents / therapeutic use*
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Antineoplastic Agents, Phytogenic / history
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / therapeutic use*
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Cyclopentane Monoterpenes
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Fruit / chemistry
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History, 21st Century
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History, Ancient
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Humans
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Olea / chemistry*
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Olive Oil / chemistry*
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Olive Oil / history
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Phenols / history
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Phenols / isolation & purification
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Phenols / therapeutic use*
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Phytotherapy* / history
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Plants, Medicinal
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Spices*
Substances
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Aldehydes
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Anti-Inflammatory Agents
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Antineoplastic Agents, Phytogenic
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Cyclopentane Monoterpenes
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Olive Oil
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Phenols
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oleocanthal