Cycling with BRCA2 from DNA repair to mitosis

Hyunsook Lee

doi:10.1016/j.yexcr.2014.10.008

Cycling with BRCA2 from DNA repair to mitosis

Exp Cell Res. 2014 Nov 15;329(1):78-84. doi: 10.1016/j.yexcr.2014.10.008. Epub 2014 Oct 16.

Author

Hyunsook Lee¹

Affiliation

¹ Department of Biological Sciences & Institute of Molecular Biology and Genetics, Seoul National University, 1 Gwanak-Ro, Gwanak-Gu, Seoul 151-742, Republic of Korea. Electronic address: HL212@snu.ac.kr.

PMID: 25447315
DOI: 10.1016/j.yexcr.2014.10.008

Abstract

Genetic integrity in proliferating cells is guaranteed by the harmony of DNA replication, appropriate DNA repair, and segregation of the duplicated genome. Breast cancer susceptibility gene BRCA2 is a unique tumor suppressor that is involved in all three processes. Hence, it is critical in genome maintenance. The functions of BRCA2 in DNA repair and homology-directed recombination (HDR) have been reviewed numerous times. Here, I will briefly go through the functions of BRCA2 in HDR and focus on the emerging roles of BRCA2 in telomere homeostasis and mitosis, then discuss how BRCA2 exerts distinct functions in a cell-cycle specific manner in the maintenance of genomic integrity.

Keywords: BRCA2; Cell cycle; HDR (homology-directed recombination); Replication fork; Spindle assembly checkpoint (SAC).

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
BRCA2 Protein / genetics*
Cell Cycle / genetics*
Cytokinesis
DNA Repair / genetics*
DNA Replication
Humans
Mitosis / genetics*

Substances

BRCA2 Protein