Gram-positive antimicrobial activity of amino acid-based hydrogels

Adv Mater. 2015 Jan 27;27(4):648-54. doi: 10.1002/adma.201403339. Epub 2014 Nov 29.

Abstract

Antimicrobial hydrogels are prepared based on the co-assembly of commercial Fmoc-phenylalanine and Fmoc-leucine, which act as the hydrogelator and antimicrobial building block, respectively. This co-assembled antimicrobial hydrogel is demonstrated to exhibit selective bactericidal activity for gram-positive bacteria while being biocompatible with normal mammalian cells, showing great potential as an antimicrobial coating for clinical anti-infective applications.

Keywords: Fmoc-amino acids; antimicrobial hydrogels; biocompatible; co-assembly; gram-positive bacteria.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / chemistry*
  • Amino Acids / pharmacology*
  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / pharmacology*
  • Fluorenes / chemistry
  • Gram-Positive Bacteria / drug effects*
  • Hydrogels / chemistry*
  • Hydrogen Bonding
  • Models, Molecular
  • Molecular Conformation

Substances

  • 9-fluorenylmethoxycarbonyl
  • Amino Acids
  • Anti-Bacterial Agents
  • Fluorenes
  • Hydrogels