Abstract
Three RSV-transformed rat cell lines: GCA, W12 and XC were characterized as to their ability to anchorage-independent growth in comparison to normal rat kidney (NRK-49F) cells. Differences in the threshold density (TD) and colony forming efficiency (CFE) of the investigated cells are described. The ability of virally transformed cells to stimulation of soft agar colony formation of NRK cells in coculture assay was presented. The production of TGFs-like factors by GCA, W12 and XC cells was suggested.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Avian Sarcoma Viruses / metabolism
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Avian Sarcoma Viruses / physiology*
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Cell Adhesion
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Cell Division
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Cell Line, Transformed / metabolism
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Cell Line, Transformed / pathology
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Cell Transformation, Viral* / drug effects
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Oncogene Proteins, Viral / metabolism
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Oncogene Proteins, Viral / pharmacology
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Rats
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Transforming Growth Factors / metabolism
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Transforming Growth Factors / pharmacology
Substances
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Oncogene Proteins, Viral
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Transforming Growth Factors