Process optimization of microencapsulation of curcumin in γ-polyglutamic acid using response surface methodology

Food Chem. 2015 Apr 1:172:497-503. doi: 10.1016/j.foodchem.2014.09.100. Epub 2014 Sep 28.

Abstract

The aim of this study was to develop an optimal microencapsulation method for an oil-soluble component (curcumin) using γ-PGA. The results show that Span80 significantly enhances the encapsulation efficiency (EE) of γ-Na(+)-PGA microcapsules. Therefore, the effects of γ-Na(+)-PGA, curcumin and Span80 concentration on EE of γ-Na(+)-PGA microcapsules were studied by means of response surface methodology (RSM). It was found that the optimal microencapsulation process is achieved by using γ-Na(+)-PGA 6.05%, curcumin 15.97% and Span80 0.61% with a high EE% (74.47 ± 0.20%). Furthermore, the models explain 98% of the variability in the responses. γ-Na(+)-PGA seems to be a good carrier for the encapsulation of curcumin. In conclusion, this simple and versatile approach can potentially be applied to the microencapsulation of various oil-soluble components for food applications.

Keywords: Curcumin; Encapsulation efficiency; Poly-γ-glutamic acid; Response surface methodology.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Curcumin / chemistry*
  • Curcumin / pharmacology
  • Drug Compounding / methods*
  • Models, Theoretical
  • Polyglutamic Acid / analogs & derivatives*
  • Polyglutamic Acid / chemistry
  • Polymers / chemistry

Substances

  • Polymers
  • poly(gamma-glutamic acid)
  • Polyglutamic Acid
  • Curcumin