Plasma levels of progranulin and interleukin-6 in frontotemporal lobar degeneration

Neurobiol Aging. 2015 Mar;36(3):1603.e1-4. doi: 10.1016/j.neurobiolaging.2014.10.023. Epub 2014 Oct 18.

Abstract

We have measured plasma progranulin and interleukin-6 in 230 patients with frontotemporal lobar degeneration (FTLD), 104 patients with Alzheimer's disease, and 161 control subjects. We have replicated previous findings of decreased levels of progranulin protein in FTLD because of mutations in GRN and show this is not observed in FTLD cases because of other causes. interleukin-6 levels were increased in FTLD overall, but these did not discriminate between clinical and genetic subtypes.

Keywords: Biomarkers; Frontotemporal Lobar degeneration; Interleukin-6; Progranulin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / diagnosis
  • Biomarkers / blood
  • Diagnosis, Differential
  • Female
  • Frontotemporal Lobar Degeneration / diagnosis*
  • Humans
  • Intercellular Signaling Peptides and Proteins / blood*
  • Interleukin-6 / blood*
  • Male
  • Middle Aged
  • Progranulins

Substances

  • Biomarkers
  • GRN protein, human
  • IL6 protein, human
  • Intercellular Signaling Peptides and Proteins
  • Interleukin-6
  • Progranulins