Emergence of CD134 cysteine-rich domain 2 (CRD2)-independent strains of feline immunodeficiency virus (FIV) is associated with disease progression in naturally infected cats

Retrovirology. 2014 Nov 28:11:95. doi: 10.1186/s12977-014-0095-7.

Abstract

Background: Feline immunodeficiency virus (FIV) infection is mediated by sequential interactions with CD134 and CXCR4. Field strains of virus vary in their dependence on cysteine-rich domain 2 (CRD2) of CD134 for infection.

Findings: Here, we analyse the receptor usage of viral variants in the blood of 39 naturally infected cats, revealing that CRD2-dependent viral variants dominate in early infection, evolving towards CRD2-independence with disease progression.

Conclusions: These findings are consistent with a shift in CRD2 of CD134 usage with disease progression.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cats
  • Disease Progression
  • Feline Acquired Immunodeficiency Syndrome / etiology*
  • Feline Acquired Immunodeficiency Syndrome / virology
  • Glycoproteins / physiology
  • Glycosylation
  • Immunodeficiency Virus, Feline / physiology*
  • Protein Structure, Tertiary
  • Receptors, OX40 / chemistry
  • Receptors, OX40 / physiology*
  • Viral Envelope Proteins / physiology
  • Viral Tropism

Substances

  • Glycoproteins
  • Receptors, OX40
  • Viral Envelope Proteins
  • envelope protein, Feline immunodeficiency virus