First human systemic infection caused by Spiroplasma

J Clin Microbiol. 2015 Feb;53(2):719-21. doi: 10.1128/JCM.02841-14. Epub 2014 Nov 26.

Abstract

Spiroplasma species are organisms that normally colonize plants and insects. We describe the first case of human systemic infection caused by Spiroplasma bacteria in a patient with hypogammaglobulinemia undergoing treatment with biological disease-modifying antirheumatic agents. Spiroplasma turonicum was identified through molecular methods in several blood cultures. The infection was successfully treated with doxycycline plus levofloxacin.

Publication types

  • Case Reports

MeSH terms

  • Agammaglobulinemia / chemically induced
  • Agammaglobulinemia / complications*
  • Aged
  • Anti-Bacterial Agents / therapeutic use
  • Blood / microbiology*
  • DNA, Bacterial / chemistry
  • DNA, Bacterial / genetics
  • Doxycycline / therapeutic use
  • Female
  • Gram-Negative Bacterial Infections / diagnosis*
  • Gram-Negative Bacterial Infections / drug therapy
  • Gram-Negative Bacterial Infections / microbiology*
  • Humans
  • Levofloxacin / therapeutic use
  • Microbiological Techniques
  • Molecular Sequence Data
  • Sepsis / diagnosis*
  • Sepsis / drug therapy
  • Sepsis / microbiology*
  • Sequence Analysis, DNA
  • Spiroplasma / isolation & purification*
  • Treatment Outcome

Substances

  • Anti-Bacterial Agents
  • DNA, Bacterial
  • Levofloxacin
  • Doxycycline

Associated data

  • GENBANK/KJ596453