CMOS image sensor-based implantable glucose sensor using glucose-responsive fluorescent hydrogel

Takashi Tokuda; Masayuki Takahashi; Kazuhiro Uejima; Keita Masuda; Toshikazu Kawamura; Yasumi Ohta; Mayumi Motoyama; Toshihiko Noda; Kiyotaka Sasagawa; Teru Okitsu; Shoji Takeuchi; Jun Ohta

doi:10.1364/BOE.5.003859

CMOS image sensor-based implantable glucose sensor using glucose-responsive fluorescent hydrogel

Biomed Opt Express. 2014 Oct 10;5(11):3859-70. doi: 10.1364/BOE.5.003859. eCollection 2014 Nov 1.

Affiliations

¹ Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5Takayama-cho, Ikoma, Nara 630-0192, Japan.
² TERUMO Co., R&D Headquarters, 1500 Inokuchi, Nakai-machi, Ashigarakami-gun, Kanagawa 259-0151, Japan.
³ Institute of Industrial Science, University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan.

Abstract

A CMOS image sensor-based implantable glucose sensor based on an optical-sensing scheme is proposed and experimentally verified. A glucose-responsive fluorescent hydrogel is used as the mediator in the measurement scheme. The wired implantable glucose sensor was realized by integrating a CMOS image sensor, hydrogel, UV light emitting diodes, and an optical filter on a flexible polyimide substrate. Feasibility of the glucose sensor was verified by both in vitro and in vivo experiments.

Keywords: (000.0000) General; (000.2700) General science.