Microfluidic platforms with monolithically integrated hierarchical apertures for the facile and rapid formation of cargo-carrying vesicles

Hyesung Cho; Junsoo Kim; Keishi Suga; Takaaki Ishigami; Hyunchul Park; Jung Won Bang; Soonmin Seo; Mansoo Choi; Pahn-Shick Chang; Hiroshi Umakoshi; Ho-Sup Jung; Kahp-Yang Suh

doi:10.1039/c4lc01096e

Microfluidic platforms with monolithically integrated hierarchical apertures for the facile and rapid formation of cargo-carrying vesicles

Lab Chip. 2015 Jan 21;15(2):373-7. doi: 10.1039/c4lc01096e.

Authors

Hyesung Cho¹, Junsoo Kim, Keishi Suga, Takaaki Ishigami, Hyunchul Park, Jung Won Bang, Soonmin Seo, Mansoo Choi, Pahn-Shick Chang, Hiroshi Umakoshi, Ho-Sup Jung, Kahp-Yang Suh

Affiliation

¹ Department of Mechanical and Aerospace Engineering, Seoul National University, Seoul, Republic of Korea. jhs@snu.ac.kr.

PMID: 25422046
DOI: 10.1039/c4lc01096e

Abstract

We fabricated a simple yet robust microfluidic platform with monolithically integrated hierarchical apertures. This platform showed efficient diffusive mixing of the introduced lipids through approximately 8000 divisions with tiny pores (~5 μm in diameter), resulting in massive, real-time production of various cargo-carrying particles via multi-hydrodynamic focusing.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Dimyristoylphosphatidylcholine / chemistry
Equipment Design
Fatty Acids, Unsaturated / chemistry
Hydrodynamics
Light
Lipids / chemistry
Liposomes / chemistry
Microfluidic Analytical Techniques / instrumentation*
Microscopy, Electron, Scanning
Porosity
Scattering, Radiation

Substances

10, 12-pentacosadiynoic acid
Fatty Acids, Unsaturated
Lipids
Liposomes
Dimyristoylphosphatidylcholine