Redox-responsive degradable honeycomb manganese oxide nanostructures as effective nanocarriers for intracellular glutathione-triggered drug release

Dinggeng He; Xiaoxiao He; Kemin Wang; Xue Yang; Xiaoxiao Yang; Zhen Zou; Xuecai Li

doi:10.1039/c4cc08172b

Redox-responsive degradable honeycomb manganese oxide nanostructures as effective nanocarriers for intracellular glutathione-triggered drug release

Chem Commun (Camb). 2015 Jan 14;51(4):776-9. doi: 10.1039/c4cc08172b.

Authors

Dinggeng He¹, Xiaoxiao He, Kemin Wang, Xue Yang, Xiaoxiao Yang, Zhen Zou, Xuecai Li

Affiliation

¹ State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Hunan University, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Changsha 410082, China. xiaoxiaohe@hnu.edu.cn kmwang@hnu.edu.cn.

PMID: 25421350
DOI: 10.1039/c4cc08172b

Abstract

Redox-responsive degradable honeycomb manganese oxide (hMnO2) nanostructures consisting of some lamellar MnO2 platelets were established as a new class of drug carriers for intracellular glutathione-triggered drug release.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibiotics, Antineoplastic / administration & dosage*
Delayed-Action Preparations / chemistry
Delayed-Action Preparations / metabolism
Doxorubicin / administration & dosage*
Drug Carriers / chemistry*
Drug Carriers / metabolism
Drug Liberation
Glutathione / metabolism*
Hep G2 Cells
Humans
Manganese Compounds / chemistry*
Manganese Compounds / metabolism
Nanostructures / chemistry*
Nanostructures / ultrastructure
Neoplasms / drug therapy
Neoplasms / metabolism
Oxidation-Reduction
Oxides / chemistry*
Oxides / metabolism

Substances

Antibiotics, Antineoplastic
Delayed-Action Preparations
Drug Carriers
Manganese Compounds
Oxides
manganese oxide
Doxorubicin
Glutathione