Chronobiological evidence for an uncoupling of the Na,K-ATPase to aldosterone in normal renin hypertension

Enzyme. 1989;41(3):159-67. doi: 10.1159/000469071.

Abstract

The Na,K-ATPase activity of erythrocyte membranes is markedly increased in normal-renin essential hypertensives. A temporal shift of the chronobiology of the erythrocyte-membrane-bound Na,K-ATPase in these patients is described. The disorder causes a loss of synchronism between the circadian rhythms of aldosterone and Na,K-ATPase. Such uncoupling phenomenon may explain the inversion of the day/night sodium excretion ratio and other disturbances of sodium metabolism found in essential hypertensives.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aldosterone / blood*
  • Aldosterone / urine
  • Circadian Rhythm*
  • Erythrocyte Membrane / enzymology*
  • Female
  • Humans
  • Hypertension / blood*
  • Hypertension / enzymology
  • Hypertension / urine
  • Male
  • Posture
  • Potassium / urine
  • Reference Values
  • Renin / blood*
  • Sodium / urine
  • Sodium-Potassium-Exchanging ATPase / blood*

Substances

  • Aldosterone
  • Sodium
  • Renin
  • Sodium-Potassium-Exchanging ATPase
  • Potassium