Evaluation of ovarian function and metabolic factors in women affected by polycystic ovary syndrome after treatment with D-Chiro-Inositol

Arch Gynecol Obstet. 2015 May;291(5):1181-6. doi: 10.1007/s00404-014-3552-6. Epub 2014 Nov 22.

Abstract

Purpose: To evaluate the effects of D-Chiro-Inositol in women affected by polycystic ovary syndrome (PCOS).

Methods: We enrolled 48 patients, with homogeneous bio-physical characteristics, affected by PCOS and menstrual irregularities. These patients underwent treatment with 1 gr of D-Chiro-Inositol/die plus 400 mcg of Folic Acid/die orally for 6 months. We analyzed pre-treatment and post-treatment BMI, Systolic and Diastolic blood pressure, Ferriman-Gallwey score, Cremoncini score, serum LH, LH/FSH ratio, total and free testosterone, DHEA-S, Δ-4-androstenedione, SHBG, prolactin, glucose/IRI ratio, HOMA index, and resumption of regular menstrual cycles.

Results: We evidenced a statistically significant reduction of systolic blood pressure, Ferriman-Gallwey score, LH, LH/FSH ratio, total Testosterone, free Testosterone, ∆-4-Androstenedione, Prolactin, and HOMA Index; in the same patients, we noticed a statistically significant increase of SHBG and Glycemia/IRI ratio. Moreover, we observed statistically significant (62.5%; p < 0.05) post-treatment menstrual cycle regularization.

Conclusions: D-Chiro-Inositol is effective in improving ovarian function and metabolism of patients affected by PCOS.

Publication types

  • Evaluation Study

MeSH terms

  • Adult
  • Blood Glucose
  • Female
  • Folic Acid / administration & dosage*
  • Folic Acid / therapeutic use
  • Follicle Stimulating Hormone / blood
  • Humans
  • Inositol / pharmacology*
  • Inositol / therapeutic use
  • Luteinizing Hormone / blood
  • Menstrual Cycle / blood
  • Menstrual Cycle / drug effects
  • Menstruation Disturbances / blood
  • Menstruation Disturbances / drug therapy*
  • Metrorrhagia / etiology
  • Metrorrhagia / prevention & control
  • Middle Aged
  • Oligomenorrhea / etiology
  • Oligomenorrhea / prevention & control
  • Ovary / physiopathology*
  • Polycystic Ovary Syndrome / blood
  • Polycystic Ovary Syndrome / drug therapy*
  • Polycystic Ovary Syndrome / metabolism
  • Prolactin / blood
  • Prospective Studies
  • Testosterone / blood
  • Treatment Outcome
  • Vitamin B Complex / pharmacology*
  • Vitamin B Complex / therapeutic use
  • Young Adult

Substances

  • Blood Glucose
  • Vitamin B Complex
  • Testosterone
  • Inositol
  • Prolactin
  • Luteinizing Hormone
  • Follicle Stimulating Hormone
  • Folic Acid