Diagnostic and post-treatment CT appearance of biopsy proven mixed Cryptococcus and Candida cholangitis

J Xray Sci Technol. 2014;22(6):727-33. doi: 10.3233/XST-140457.

Abstract

Cryptococcus neoformans and Candida are common opportunistic pathogens of human. There is very limited literature on Cryptococcus neoformans cholangitis or Candida cholangitis in immunocompetent patient while mixed Cryptococcus neoformans and Candida cholangitis has not been reported in the literature ever before. We hereby report the imaging findings of a case of mixed Cryptococcus neoformans and Candida cholangitis in an immunocompetent boy. The CT features included nodules in the cystic duct and common bile duct, dilatation of the intra- and extrahepatic bile ducts with mural thickening, irregular hypodense mass-like lesion extending along the bile ducts from the liver hilum to the periphery which was confirmed by the presence of enlarged and confluent lymph nodes. CT characteristics can contribute to timely diagnosis and treatment of this disease.

Keywords: Bile duct; candida; computed tomography; cryptococcus; fungal infection.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / therapeutic use
  • Biopsy
  • Candida / isolation & purification
  • Candidiasis / diagnostic imaging*
  • Candidiasis / drug therapy
  • Candidiasis / microbiology
  • Child, Preschool
  • Cholangitis / diagnostic imaging*
  • Cholangitis / drug therapy
  • Cholangitis / microbiology
  • Coinfection / diagnostic imaging*
  • Coinfection / drug therapy
  • Coinfection / microbiology
  • Common Bile Duct / diagnostic imaging
  • Common Bile Duct / microbiology
  • Common Bile Duct / pathology
  • Cryptococcosis / diagnostic imaging*
  • Cryptococcosis / drug therapy
  • Cryptococcosis / mortality
  • Cryptococcus neoformans / isolation & purification
  • Humans
  • Male
  • Tomography, X-Ray Computed / methods

Substances

  • Antifungal Agents