A novel leucine zipper motif-based hybrid peptide delivers a functional peptide cargo inside cells

Chem Commun (Camb). 2015;51(2):413-6. doi: 10.1039/c4cc07459a. Epub 2014 Nov 18.

Abstract

A hybrid comprising an autophagy-inducing peptide (AIP) and a cell-penetrating peptide (CPP) connected via heterodimeric leucine zippers was generated and delivered into cells. The hybrid successfully induced autophagy without significant cell death, while the same AIP directly connected to a CPP caused both autophagy and significant cell death.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Autophagy / drug effects*
  • Cell-Penetrating Peptides / chemistry*
  • HeLa Cells
  • Humans
  • Leucine Zippers*
  • Molecular Sequence Data
  • Peptides / administration & dosage
  • Peptides / chemistry*
  • Peptides / pharmacology*

Substances

  • Cell-Penetrating Peptides
  • Peptides