Efficient Cu(OTf)2-catalyzed synthesis of novel and diverse 2,3-dihydroquinazolin-4(1H)-ones

Mol Divers. 2015 Feb;19(1):67-75. doi: 10.1007/s11030-014-9557-z. Epub 2014 Nov 18.

Abstract

An efficient one-pot synthesis of various 2,3-dihydroquinazolin-4(1H)-one derivatives was accomplished using Cu(OTf)2-catalyzed multi-component reactions between isatoic anhydride, ketones, and amines. The method has several significant advantages; mild reaction conditions, easy handling, and efficiency of catalyst.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amines / chemistry
  • Chemistry Techniques, Synthetic
  • Copper / chemistry*
  • Ketones / chemistry
  • Mesylates / chemistry*
  • Models, Molecular
  • Oxazines / chemistry
  • Quinazolinones / chemical synthesis*
  • Quinazolinones / chemistry*

Substances

  • Amines
  • Ketones
  • Mesylates
  • Oxazines
  • Quinazolinones
  • Copper
  • trifluoromethanesulfonic acid
  • isatoic anhydride