Abstract
The new 2-acetyl-8-methoxynaphthol (1) and five new "dimeric" napthopyranones, karwinaphthopyranones A1 and A2 (2 and 3) and karwinaphthopyranones B1-B3 (4-6), possessing a methoxy group at C-5', were isolated together with four other known compounds from the dried fruits of Karwinskia parvifolia. The structures of compounds 2-6 were determined by spectroscopic data interpretation. Cell culture assays showed that some of these compounds possess antiproliferative activities in representative human cancer cell lines, with half-maximal growth inhibitory concentrations in the micromolar range.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antineoplastic Agents, Phytogenic / chemistry
-
Antineoplastic Agents, Phytogenic / isolation & purification*
-
Antineoplastic Agents, Phytogenic / pharmacology*
-
Drug Screening Assays, Antitumor
-
Fruit / chemistry
-
HCT116 Cells
-
Hep G2 Cells
-
Humans
-
Karwinskia / chemistry*
-
Molecular Structure
-
Naphthols / chemistry
-
Naphthols / isolation & purification*
-
Naphthols / pharmacology*
-
Pyrones / chemistry
-
Pyrones / isolation & purification*
-
Pyrones / pharmacology*
Substances
-
2-acetyl-8-methoxynaphthol
-
Antineoplastic Agents, Phytogenic
-
Naphthols
-
Pyrones
-
karwinaphthopyranone A1