Abstract
Systemic Epstein-Barr virus-positive T/natural killer-cell lymphoproliferative disorder (EBV + LPD) has predominantly been observed among pediatric patients as a life-threatening condition. The present study presents a rare case of EBV + LPD in an adult with good outcome. This patient's history is more than 2 years and her condition was stable. She received 6 cycles of chemotherapy cyclophosphamide/doxorubicin/vincristine/prednisolone (CHOP). The evaluation was complete remission. The low levels of EBV-DNA in the peripheral blood may have potential benefit factor for the sensitivity to the chemotherapy and good outcome.
Keywords:
Epstein-Barr virus; T/natural killer-cell; lymphoproliferative disorder.
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Biomarkers, Tumor / analysis
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Biopsy
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Cyclophosphamide / administration & dosage
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Doxorubicin / administration & dosage
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Epstein-Barr Virus Infections / diagnosis
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Epstein-Barr Virus Infections / metabolism
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Epstein-Barr Virus Infections / virology*
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Female
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Humans
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Immunohistochemistry
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Killer Cells, Natural / chemistry
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Killer Cells, Natural / virology*
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Lymphoproliferative Disorders / diagnosis
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Lymphoproliferative Disorders / metabolism
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Lymphoproliferative Disorders / virology*
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Magnetic Resonance Imaging
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Middle Aged
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Prednisolone / administration & dosage
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T-Lymphocytes, Cytotoxic / chemistry
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T-Lymphocytes, Cytotoxic / virology*
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Time Factors
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Tomography, X-Ray Computed
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Treatment Outcome
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Vincristine / administration & dosage
Substances
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Biomarkers, Tumor
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Vincristine
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Doxorubicin
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Cyclophosphamide
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Prednisolone