High-level azithromycin-resistant Neisseria gonorrhoeae clinical isolate in France, March 2014

Euro Surveill. 2014 Nov 6;19(44):20951. doi: 10.2807/1560-7917.es2014.19.44.20951.

Abstract

We report the first case in France of a high-level azithromycin-resistant Neisseria gonorrhoeae (minimum inhibitory concentration (MIC) = 96 mg/L) assigned to MLST7363 (NG-MAST ST6360), also resistant to ciprofloxacin and tetracycline but susceptible to ceftriaxone. The patient was a 51 year-old heterosexual man who returned following 1g azithromycin monotherapy. Mechanisms of azithromycin resistance were a C2599T mutation in the four copies of the rrl gene and a novel mutation in the promoter of the mtrR gene.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / therapeutic use*
  • Azithromycin / therapeutic use*
  • Drug Resistance, Bacterial*
  • France
  • Gonorrhea / drug therapy*
  • Gonorrhea / microbiology
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Neisseria gonorrhoeae / drug effects*
  • Neisseria gonorrhoeae / genetics
  • Neisseria gonorrhoeae / isolation & purification*
  • Sequence Analysis, DNA
  • Spectinomycin / therapeutic use
  • Treatment Outcome

Substances

  • Anti-Bacterial Agents
  • Azithromycin
  • Spectinomycin