Dihydroxanthenones from the fermentation product of an endophytic fungus Gliomastix murorum

J Asian Nat Prod Res. 2015;17(4):319-23. doi: 10.1080/10286020.2014.980240. Epub 2014 Nov 12.

Abstract

Three new dihydroxanthones, muroxanthenones A-C (1-3), together with three known dihydroxanthones (4-6) were isolated from the fermentation products of an endophytic fungus Gliomastix murorum. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compound 3 showed high cytotoxicities against NB4 and PC3 cell with IC(50) values of 2.2 and 2.8 μM. The other compounds also showed moderate cytotoxicities for some tested cell lines with IC(50) values between 4.1 and 9.5 μM.

Keywords: Gliomastix murorum; cytotoxicity; dihydroxanthenone; structure elucidation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Drug Screening Assays, Antitumor
  • Female
  • Fermentation
  • Humans
  • Hypocreales / chemistry*
  • Inhibitory Concentration 50
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Rhizome / chemistry
  • Xanthones / chemistry
  • Xanthones / isolation & purification*
  • Xanthones / pharmacology

Substances

  • Antineoplastic Agents
  • Xanthones
  • muroxanthenone A
  • muroxanthenone B
  • muroxanthenone C