Evaluating 3D-printed biomaterials as scaffolds for vascularized bone tissue engineering

Adv Mater. 2015 Jan 7;27(1):138-44. doi: 10.1002/adma.201403943. Epub 2014 Nov 11.

Abstract

There is an unmet need for a consistent set of tools for the evaluation of 3D-printed constructs. A toolbox developed to design, characterize, and evaluate 3D-printed poly(propylene fumarate) scaffolds is proposed for vascularized engineered tissues. This toolbox combines modular design and non-destructive fabricated design evaluation, evaluates biocompatibility and mechanical properties, and models angiogenesis.

Keywords: 3D printing; scaffolds; tissue engineering; vascularization.

Publication types

  • Evaluation Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biocompatible Materials / chemistry*
  • Bone and Bones / blood supply
  • Bone and Bones / physiology*
  • Fumarates / chemistry
  • Imaging, Three-Dimensional
  • Materials Testing / methods*
  • Models, Biological
  • Neovascularization, Physiologic
  • Platelet Endothelial Cell Adhesion Molecule-1 / metabolism
  • Polypropylenes / chemistry
  • Porosity
  • Printing, Three-Dimensional*
  • Rats, Sprague-Dawley
  • Tissue Engineering / methods*
  • Tissue Scaffolds / chemistry*
  • X-Ray Microtomography

Substances

  • Biocompatible Materials
  • Fumarates
  • Platelet Endothelial Cell Adhesion Molecule-1
  • Polypropylenes
  • poly(propylene fumarate)