Objectives: Phthalates are environmental chemicals with reproductive toxicity and estrogenic effects in animals. They are of increasing concern to human health.
Aim: To determine whether phthalate levels in semen were associated with infertility.
Methods: Using semen samples from 107 infertile and 94 fertile men, the presence and quantity of five phthalate esters were measured using high-performance liquid chromatography (HPLC). Using data collected from questionnaires and clinical examinations, the correlation between phthalate exposure and semen quality was analyzed.
Results: The cumulative levels of the measured phthalate esters were significantly higher in the infertility group compared to the control group (P<0·05). Concentrations of the five phthalate esters in men varied by age with older men showing higher cumulative levels.
Conclusions: The presence of phthalates may contribute to male infertility in our study population.
Keywords: High-performance liquid chromatography; Male infertility,; Phthalates,; Semen,.