Abstract
Single-walled carbon nanotubes (SWCNTs) coated or functionalized with PEG chains of different molecular weight were assessed for their propensity to undergo biodegradation under in vitro conditions using recombinant myeloperoxidase (MPO) or ex vivo using freshly isolated primary human neutrophils. Our findings suggest that under natural conditions, a combined process of 'stripping' (i.e., defunctionalization) and biodegradation of PEG-SWCNTs might occur and that PEG-SWCNTs are a promising--and degradable--nanomedicine vector.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Cells, Cultured
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Coated Materials, Biocompatible / chemical synthesis
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Drug Design
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Drug Implants / chemistry*
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Humans
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Molecular Weight
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Nanocapsules / chemistry*
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Nanocapsules / ultrastructure
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Nanotubes, Carbon / chemistry*
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Nanotubes, Carbon / ultrastructure
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Neutrophils / enzymology*
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Particle Size
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Peroxidase / chemistry*
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Polyethylene Glycols / chemistry*
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Substrate Specificity
Substances
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Coated Materials, Biocompatible
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Drug Implants
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Nanocapsules
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Nanotubes, Carbon
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Polyethylene Glycols
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Peroxidase