90d Exposure to Nonylphenol has Adverse Effects on the Spermatogenesis and Sperm Maturation of Adult Male Rats

Biomed Environ Sci. 2014 Nov;27(11):907-11. doi: 10.3967/bes2014.128.

Abstract

This study was conducted to elucidate the reproductive effect of NP on testis, epididymis and epididymal sperm in vivo. Adult male Sprague-Dawley rats were gavaged with NP at 0, 40, 100, or 250 mg/kg body weight (bw) on alternate days for 90 d. The results showed that oral administration of NP may damage the structure and function of testis, induce apoptosis and oxidative stress in epididymis or even have cytotoxic effects on epididymal sperm.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Animals
  • Apoptosis / drug effects
  • Dose-Response Relationship, Drug
  • Epididymis / drug effects*
  • Epididymis / metabolism
  • Epididymis / pathology
  • Male
  • Oxidative Stress / drug effects
  • Phenols / adverse effects*
  • Rats, Sprague-Dawley
  • Sperm Motility / drug effects
  • Spermatogenesis / drug effects*
  • Spermatozoa / drug effects*
  • Spermatozoa / metabolism
  • Spermatozoa / pathology
  • Testis / drug effects*
  • Testis / metabolism
  • Testis / pathology
  • Testosterone / blood

Substances

  • Phenols
  • Testosterone
  • nonylphenol