Abstract
Two porphyrin-bridged tetranuclear platinum(II) complexes are found to effectively stabilize various kinds of G-quadruplexes. Their clover-like shape endows them with the capability of targeting G-quadruplexes rather than the double-stranded structure. Their excellent anticancer activity is the result of a dual effect, inhibition of the telomerase activity and repression of oncogene expression.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology*
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Cell Cycle / drug effects
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G-Quadruplexes / drug effects*
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HeLa Cells
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Humans
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Neoplasms / drug therapy
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Organoplatinum Compounds / chemistry*
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Organoplatinum Compounds / pharmacology*
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Porphyrins / chemistry
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Porphyrins / pharmacology
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Telomerase / antagonists & inhibitors
Substances
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Antineoplastic Agents
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Organoplatinum Compounds
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Porphyrins
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Telomerase