Abstract
The fate of mRNA can be regulated by internal base modifications, with the currently known modified bases being N6-methyladenosine, 5-methylcytosine, and inosine. Three new studies show that yeast and human mRNA also contain pseudouridine residues and that pseudouridylation is induced in various stress states, hinting at a new pathway for post-transcriptional control of mRNA.
MeSH terms
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5-Methylcytosine / metabolism
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Adenosine / analogs & derivatives
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Adenosine / metabolism
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Humans
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Inosine / metabolism
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Pseudouridine / metabolism*
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RNA Processing, Post-Transcriptional*
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RNA, Messenger / genetics
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RNA, Messenger / metabolism*
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Saccharomyces cerevisiae / genetics
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Saccharomyces cerevisiae / metabolism*
Substances
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RNA, Messenger
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Pseudouridine
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Inosine
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5-Methylcytosine
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N-methyladenosine
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Adenosine