Simultaneous co-ingestion of prescription stimulants, alcohol and other drugs: a multi-cohort national study of US adolescents

Hum Psychopharmacol. 2015 Jan;30(1):42-51. doi: 10.1002/hup.2449. Epub 2014 Nov 5.

Abstract

Objective: To determine the past-year prevalence rates and correlates of simultaneous co-ingestion of prescription stimulants and other substances among US high school seniors.

Methods: Nationally representative probability samples of US high school seniors were surveyed as a part of the Monitoring the Future study. The sample consisted of five cohorts including a total of 12,431 high school seniors (modal age: 18 years) and represented a population that was 53% female.

Results: Among past-year nonmedical users of prescription stimulants (n = 835), the estimated prevalence of any past-year simultaneous co-ingestion of prescription stimulants and other substances was 64.4%. The substances most commonly co-ingested with prescription stimulants included marijuana (51.1%) and alcohol (48.4%). Nonmedical users who co-ingested prescription stimulants with other substances were more likely to report non-oral routes of administration, recreational motives and greater subjective high when using prescription stimulants than nonmedical users who did not co-ingest prescription stimulants with other substances.

Conclusions: The majority of past-year nonmedical users of prescription stimulants reported simultaneous co-ingestion of prescription stimulants and other substances. The findings indicate that co-ingestion of prescription stimulants and other substances is a pervasive behavior among US adolescents who engage in nonmedical use of prescription stimulants and should be carefully considered in future clinical practice and research.

Keywords: adolescents; co-ingestion; polydrug use; prescription stimulants; simultaneous use.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Central Nervous System Agents*
  • Cohort Studies
  • Cross-Sectional Studies
  • Demography
  • Ethanol*
  • Female
  • Humans
  • Male
  • Prescription Drugs*
  • Prevalence
  • Smoking*
  • Substance-Related Disorders / epidemiology*
  • Surveys and Questionnaires
  • United States / epidemiology

Substances

  • Central Nervous System Agents
  • Prescription Drugs
  • Ethanol