Abstract
Total syntheses of structurally and biologically intriguing natural products relying on new synthetic methodologies are described. This article features cinchona alkaloid-catalyzed asymmetric Morita-Baylis-Hillman reactions, heterocycle syntheses based on rhodium-catalyzed C-H amination and indium-catalyzed Conia-ene reactions, and their utilization for the syntheses of the phoslactomycin family of antibiotics, glutamate receptor agonists and antagonists, and alkaloids with characteristic highly substituted pyrrolidinone core structures.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Alkaloids / chemical synthesis*
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Alkaloids / chemistry
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / chemistry
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Biological Products / chemical synthesis*
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Biological Products / chemistry
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Catalysis
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Chemistry Techniques, Synthetic / methods*
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Cinchona Alkaloids / chemistry
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Excitatory Amino Acid Agents / chemical synthesis*
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Excitatory Amino Acid Agents / chemistry
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Excitatory Amino Acid Agonists / chemical synthesis
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Excitatory Amino Acid Agonists / chemistry
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Excitatory Amino Acid Antagonists / chemical synthesis
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Excitatory Amino Acid Antagonists / chemistry
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Indium / chemistry
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Lactones / chemical synthesis*
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Lactones / chemistry
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Rhodium / chemistry
Substances
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Alkaloids
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Anti-Bacterial Agents
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Biological Products
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Cinchona Alkaloids
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Excitatory Amino Acid Agents
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Excitatory Amino Acid Agonists
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Excitatory Amino Acid Antagonists
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Lactones
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Indium
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Rhodium