Primary intravascular large B-cell lymphoma of the lung: a review and case report

Yanfan Chen; Cheng Ding; Quan Lin; Kaiyan Yang; Yuping Li; Shaoxian Chen

doi:10.3978/j.issn.2072-1439.2014.08.45

Primary intravascular large B-cell lymphoma of the lung: a review and case report

J Thorac Dis. 2014 Oct;6(10):E242-5. doi: 10.3978/j.issn.2072-1439.2014.08.45.

Authors

Yanfan Chen¹, Cheng Ding¹, Quan Lin¹, Kaiyan Yang¹, Yuping Li¹, Shaoxian Chen¹

Affiliation

¹ 1 Department of Respiration, Zhejiang Chinese Medical University, Hangzhou 310000, China ; 2 Department of Respiration, 3 Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.

PMID: 25364541
PMCID: PMC4215148
DOI: 10.3978/j.issn.2072-1439.2014.08.45

Abstract

Objective: To investigate the clinicopathological features of primary intravascular large B-cell lymphoma (IVLBCL) of the lung.

Methods: Histopathological and clinical data based on lung biopsy were analyzed and used to diagnose a patient with IVLBCL of the lung.

Results: Fever and respiratory symptoms were the main presentations, lung biopsy revealed lymphoma cells in the lumen of small blood vessels. Tumor cells expressed Bcl-2, the Bcl-6, CD20, Ki67, MUM-1, Pax5, CD, CD30, and vascular endothelial CD34.

Conclusions: Primary pulmonary IVLBCL of the lung is extremely rare, on chest CT it manifests as diffuse ground glass shadow, or nodular consolidations in the lung, lactate dehydrogenase and C-reactive protein was found to increase, fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) is an important and significant diagnostic modality in its early diagnosis. Also, bronchial lung biopsy has the advantage of less trauma and high sensitive rate. R-CHOP is the main treatment for lung primary pulmonary IVLBCL of the lung; however, its prognosis is relatively poor.

Keywords: Intravascular lymphoma; case report; large B-cell; lung.

Publication types

Case Reports