Synthesis and antimicrobial activity of new norbornyl system based oxadiazole thioglycosides and acyclic nucleoside analogs

Acta Pol Pharm. 2014 Sep-Oct;71(5):771-80.

Abstract

New sugar hydrazones linked to norbornyl ring system, their oxadiazole acyclic nucleoside analogs and the corresponding thioglycosides were synthesized. The synthesized compounds were tested for their antimicrobial activity and displayed different degrees of activities or inhibitory actions. Their oxadiazole acyclic nucleoside analogs and thioglycosides showed higher activities.

Publication types

  • Comparative Study

MeSH terms

  • Anti-Infective Agents / chemical synthesis*
  • Anti-Infective Agents / pharmacology*
  • Bacillus subtilis / drug effects
  • Bacillus subtilis / growth & development
  • Microbial Sensitivity Tests
  • Norbornanes / chemical synthesis*
  • Norbornanes / pharmacology*
  • Nucleosides / chemical synthesis*
  • Nucleosides / pharmacology*
  • Oxadiazoles / chemical synthesis*
  • Oxadiazoles / pharmacology*
  • Pseudomonas aeruginosa / drug effects
  • Pseudomonas aeruginosa / growth & development
  • Streptomyces / drug effects
  • Streptomyces / growth & development
  • Thioglycosides / chemical synthesis*
  • Thioglycosides / pharmacology*

Substances

  • Anti-Infective Agents
  • Norbornanes
  • Nucleosides
  • Oxadiazoles
  • Thioglycosides