Five new taraxerene-type triterpenes from the branch barks of Davidia involucrata

Molecules. 2014 Oct 30;19(11):17619-31. doi: 10.3390/molecules191117619.

Abstract

Five new taraxerene-type triterpenes, 2-nor-D-friedoolean-14-en-28-ol (1), 2-nor-d-friedoolean-14-en-3α,28-diol (2), 6α-hydroxy-2-nor-D-friedoolean-14-en-3,21-dione (3), 6α,11α,29-trihydroxy-D-friedoolean-14-en-3,16,21-trione (4), and 6α,23,29-trihydroxy-D-friedoolean-14-en-3,16,21-trione (5), were isolated from the MeOH extract of the branch barks of Davidia involucrata, together with five known compounds. Their structures were elucidated by means of various spectroscopic analyses. Five of the identified compounds showed moderate cytotoxicities against the cell proliferation of SGC-7901, MCF-7, and BEL-7404.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Cell Line, Tumor
  • Cornaceae / chemistry*
  • Humans
  • MCF-7 Cells
  • Molecular Structure
  • Spectrum Analysis / methods
  • Triterpenes / chemistry*
  • Triterpenes / pharmacology

Substances

  • Antineoplastic Agents, Phytogenic
  • Triterpenes