Applying synthetic lethality for the selective targeting of cancer

N Engl J Med. 2014 Oct 30;371(18):1725-35. doi: 10.1056/NEJMra1407390.
No abstract available

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / therapeutic use
  • DNA Repair*
  • Drug Discovery
  • Genes, Lethal*
  • Genes, myc
  • Humans
  • Mutation*
  • Neoplasms / genetics*
  • Neoplasms / therapy*
  • Poly(ADP-ribose) Polymerase Inhibitors
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins p21(ras)
  • ras Proteins / genetics

Substances

  • Antineoplastic Agents
  • KRAS protein, human
  • Poly(ADP-ribose) Polymerase Inhibitors
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins p21(ras)
  • ras Proteins