A Double Hit CD10-Negative B-Cell Lymphoma with t(3;8)(q27;q24) Leading to Juxtaposition of the BCL6 and MYC Loci Associated with Good Clinical Outcome

Lucinda Sanders; Sandrine Jayne; Ben Kennedy; Fiona Miall; Sietse M Aukema; Reiner Siebert; Simon D Wagner; Martin J S Dyer

doi:10.1155/2014/120714

A Double Hit CD10-Negative B-Cell Lymphoma with t(3;8)(q27;q24) Leading to Juxtaposition of the BCL6 and MYC Loci Associated with Good Clinical Outcome

Case Rep Hematol. 2014:2014:120714. doi: 10.1155/2014/120714. Epub 2014 Oct 1.

Authors

Lucinda Sanders¹, Sandrine Jayne², Ben Kennedy¹, Fiona Miall¹, Sietse M Aukema³, Reiner Siebert³, Simon D Wagner⁴, Martin J S Dyer⁵

Affiliations

¹ Department of Haematology, University Hospitals of Leicester, Leicester LE1 5WW, UK.
² Ernest and Helen Scott Haematological Research Institute and Department of Biochemistry, University of Leicester, Leicester LE1 9HN, UK.
³ Christian-Albrechts-University Kiel and Universitatsklinikum Schleswig-Holstein, Campus Kiel, Arnold Heller Straße 3, 24105 Kiel, Germany.
⁴ Ernest and Helen Scott Haematological Research Institute and Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester LE1 9HN, UK.
⁵ Ernest and Helen Scott Haematological Research Institute and Department of Biochemistry, University of Leicester, Leicester LE1 9HN, UK ; Ernest and Helen Scott Haematological Research Institute and Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester LE1 9HN, UK.

Abstract

The WHO classification of lymphomas allows for a group of diseases that have features intermediate between those of Burkitt lymphoma and diffuse large B-cell lymphoma. These are a diverse group of diseases whose genetics and clinical course are yet to be fully described. We report an unusual case of high grade B-cell lymphoma, intermediate between DLBCL and BL, lacking CD10 expression in which the chromosomal translocation t(3;8)(q27;q24) was found to be the sole chromosomal abnormality. FISH analysis demonstrated juxtaposition of the BCL6 and MYC loci without obvious involvement of the IGH locus, suggesting constitutive MYC expression due to promoter substitution. The patient responded to intensive chemotherapy and remains in remission two years after finishing therapy.