Galectin-1 and immune suppression during radiotherapy

Clin Cancer Res. 2014 Dec 15;20(24):6230-2. doi: 10.1158/1078-0432.CCR-14-2702. Epub 2014 Oct 27.

Abstract

Radiotherapy induces galectin-1 (Gal-1) secretion by tumors, which induces CD8(+) T-cell apoptosis and lymphopenia. These effects are substantially decreased by Gal-1 shRNA. Inhibition of Gal-1 may be an effective strategy for overcoming radiation-induced lymphopenia, which may improve clinical outcomes.

Publication types

  • Comment

MeSH terms

  • Animals
  • Apoptosis / radiation effects*
  • Carcinoma, Non-Small-Cell Lung / metabolism*
  • Carcinoma, Non-Small-Cell Lung / radiotherapy*
  • Galectin 1 / metabolism*
  • Humans
  • Lung Neoplasms / metabolism*
  • Lung Neoplasms / radiotherapy*
  • Lymphopenia / metabolism*

Substances

  • Galectin 1