Abstract
Along with the increase in aging of our population, the proportion of older patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) is on the rise as a result of the accumulation of comorbidities as well as biological processes associated with aging. Older patients with acute kidney injury (AKI) comprise an increasing proportion of patients with CKD/ESRD as well. In this review, we will discuss biological processes of aging that predispose patients to AKI and CKD.
2014 S. Karger AG, Basel.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Acute Kidney Injury / pathology
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Acute Kidney Injury / physiopathology
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Aged
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Aged, 80 and over
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Aging / physiology*
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Animals
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Cellular Senescence
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Disease Models, Animal
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Epithelial Cells / pathology
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Female
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Glucuronidase / physiology
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Humans
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Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
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Kidney / growth & development
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Kidney / pathology
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Kidney / physiology*
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Kidney Diseases / epidemiology
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Klotho Proteins
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Male
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Pioglitazone
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Regeneration / physiology*
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Reperfusion Injury / pathology
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Reperfusion Injury / physiopathology
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Telomere Homeostasis
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Thiazolidinediones / therapeutic use
Substances
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Hydroxymethylglutaryl-CoA Reductase Inhibitors
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Thiazolidinediones
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Glucuronidase
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Klotho Proteins
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Pioglitazone