Aging is a consequence of an organism's evolution, where specific traits that lead to the organism's development eventually promote aged phenotypes or could lead to age-related diseases. In this sense, one theory that broadly explored development and its association to aging is the developmental aging theory (DevAge), which also encompasses most known age-associated theories. Thus, we employed different systems biology tools to prospect developmental and aging-associated networks for human and murine models for evolutionary comparison. The gathered data suggest a model where proteins related to inflammation, development, epigenetic mechanisms and oxygen homeostasis coordinate the interplay between development and aging. Moreover, the mechanism also appears to be evolutionary conserved in both mammalian models, further corroborating the DevAge molecular model.
2015 S. Karger AG, Basel.