The adsorption of poly(N-isopropyl acrylamide) (PNIPAM) onto talc from aqueous solutions has been studied using the in situ methodology of particle film attenuated total reflection (ATR) Fourier transform infrared (FTIR) spectroscopy. PNIPAM was observed to adsorb significantly onto the talc particle film at a temperature below its lower critical solution temperature (LCST). Peak shifts were seen in the adsorbed layer FTIR spectrum that match those observed when PNIPAM solution is heated above its LCST. This observation indicates that adsorption causes a conformational re-arrangement similar to that seen when PNIPAM undergoes a coil-to-globule transition, in this case presumably induced by hydrophobic interactions between PNIPAM and the talc basal plane surface. The kinetics of adsorption are seen to be complex, with potential influences of conformational rearrangement and differential adsorption kinetics for the two dominant surface regions of talc particles. The adsorbed PNIPAM was seen to be exceptionally resistant to removal, with no desorption occurring when a background electrolyte solution was flowed over the adsorbed layer. Spectra acquired of the adsorbed polymer layer heated above the LCST reveal that a further conformational rearrangement takes place for the adsorbed layer, finalizing the transition from coil-to-globule that was initiated by the interaction with the mineral surface.