Shining light on the dark side of imaging: excited state absorption enhancement of a bis-styryl BODIPY photoacoustic contrast agent

Mathieu Frenette; Maryam Hatamimoslehabadi; Stephanie Bellinger-Buckley; Samir Laoui; Jeffrey La; Seema Bag; Srivalleesha Mallidi; Tayyaba Hasan; Brett Bouma; Chandra Yelleswarapu; Jonathan Rochford

doi:10.1021/ja508600x

Shining light on the dark side of imaging: excited state absorption enhancement of a bis-styryl BODIPY photoacoustic contrast agent

J Am Chem Soc. 2014 Nov 12;136(45):15853-6. doi: 10.1021/ja508600x. Epub 2014 Oct 28.

Authors

Mathieu Frenette¹, Maryam Hatamimoslehabadi, Stephanie Bellinger-Buckley, Samir Laoui, Jeffrey La, Seema Bag, Srivalleesha Mallidi, Tayyaba Hasan, Brett Bouma, Chandra Yelleswarapu, Jonathan Rochford

Affiliation

¹ Department of Chemistry and ‡Department of Physics, University of Massachusetts Boston , 100 Morrissey Boulevard, Boston, Massachusetts 02125, United States.

Abstract

A first approach toward understanding the targeted design of molecular photoacoustic contrast agents (MPACs) is presented. Optical and photoacoustic Z-scan spectroscopy was used to identify how nonlinear (excited-state) absorption contributes to enhancing the photoacoustic emission of the curcuminBF2 and bis-styryl (MeOPh)2BODIPY dyes relative to Cy3.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Absorption, Physicochemical*
Boron Compounds / chemistry*
Coloring Agents / chemistry
Contrast Media / chemistry*
Drug Design
Optical Imaging / methods*
Photoacoustic Techniques / methods*

Substances

4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
Boron Compounds
Coloring Agents
Contrast Media

Abstract

Publication types

MeSH terms

Substances

Grants and funding