A hierarchical-based classification method was designed to develop time series land-use/land-cover datasets from Landsat images between 1977 and 2008 in Lucas do Rio Verde, Mato Grosso, Brazil. A post-classification comparison approach was used to examine land-use/land-cover change trajectories, which emphasis is on the conversions from vegetation or agropasture to impervious surface area, from vegetation to agropasture, and from agropasture to regenerating vegetation. Results of this research indicated that increase in impervious surface area mainly resulted from the loss of cerrado in the initial decade of the study period and from loss of agricultural lands in the last two decades. Increase in agropasture was mainly at the expense of losing cerrado in the first two decades and relatively evenly from the loss of primary forest and cerrado in the last decade. When impervious surface area was less than approximately 40 km2 before 1999, impervious surface area was negatively related to cerrado and forest, and positively related to agropasture areas, but after impervious surface area reached 40 km2 in 1999, no obvious relationship exists between them.