Two-photon excitation of porphyrin-functionalized porous silicon nanoparticles for photodynamic therapy

Adv Mater. 2014 Dec 3;26(45):7643-8. doi: 10.1002/adma.201403415. Epub 2014 Oct 17.

Abstract

Porous silicon nanoparticles (pSiNPs) act as a sensitizer for the 2-photon excitation of a pendant porphyrin using NIR laser light, for imaging and photodynamic therapy. Mannose-functionalized pSiNPs can be vectorized to MCF-7 human breast cancer cells through a mannose receptor-mediated endocytosis mechanism to provide a 3-fold enhancement of the 2-photon PDT effect.

Keywords: mannose; nanoparticle; photodynamic therapy; porous silicon; two-photon excitation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Biocompatible Materials / chemistry
  • Biocompatible Materials / therapeutic use
  • Cell Death / drug effects
  • Cell Death / radiation effects
  • Endocytosis / drug effects
  • Endocytosis / radiation effects
  • Humans
  • Infrared Rays
  • MCF-7 Cells
  • Mannose / chemistry
  • Mannose / therapeutic use
  • Microscopy, Confocal
  • Microscopy, Fluorescence
  • Nanoparticles / chemistry
  • Nanoparticles / therapeutic use*
  • Photochemotherapy / methods*
  • Photons
  • Photosensitizing Agents / chemistry
  • Photosensitizing Agents / therapeutic use*
  • Porosity
  • Porphyrins / chemistry
  • Porphyrins / therapeutic use*
  • Silicon / chemistry
  • Silicon / therapeutic use*

Substances

  • Biocompatible Materials
  • Photosensitizing Agents
  • Porphyrins
  • Mannose
  • Silicon