Abstract
Porous silicon nanoparticles (pSiNPs) act as a sensitizer for the 2-photon excitation of a pendant porphyrin using NIR laser light, for imaging and photodynamic therapy. Mannose-functionalized pSiNPs can be vectorized to MCF-7 human breast cancer cells through a mannose receptor-mediated endocytosis mechanism to provide a 3-fold enhancement of the 2-photon PDT effect.
Keywords:
mannose; nanoparticle; photodynamic therapy; porous silicon; two-photon excitation.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Biocompatible Materials / chemistry
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Biocompatible Materials / therapeutic use
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Cell Death / drug effects
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Cell Death / radiation effects
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Endocytosis / drug effects
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Endocytosis / radiation effects
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Humans
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Infrared Rays
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MCF-7 Cells
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Mannose / chemistry
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Mannose / therapeutic use
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Microscopy, Confocal
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Microscopy, Fluorescence
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Nanoparticles / chemistry
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Nanoparticles / therapeutic use*
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Photochemotherapy / methods*
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Photons
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Photosensitizing Agents / chemistry
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Photosensitizing Agents / therapeutic use*
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Porosity
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Porphyrins / chemistry
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Porphyrins / therapeutic use*
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Silicon / chemistry
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Silicon / therapeutic use*
Substances
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Biocompatible Materials
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Photosensitizing Agents
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Porphyrins
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Mannose
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Silicon