Mutational analysis of TOX3 in Chinese Han women with polycystic ovary syndrome

Reprod Biomed Online. 2014 Dec;29(6):752-5. doi: 10.1016/j.rbmo.2014.08.004. Epub 2014 Sep 27.

Abstract

A previous genome-wide association study of polycystic ovary syndrome (PCOS) identified several susceptibility loci. TOX3 is the nearest gene to signal rs4784165. In the present study, all exons and exon-intron boundaries of TOX3 were amplified and sequenced in 200 Chinese women with PCOS. A 3-bp nucleotide deletion of CAG repeat and two known single nucleotide polymorphisms were identified. No plausible pathogenic mutations were detected. The results suggest that mutations in TOX3 are not common in Chinese Han women with PCOS.

Keywords: Keywords:; TOX3; mutation; polycystic ovary syndrome; single-nucleotide polymorphism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apoptosis Regulatory Proteins
  • Asian People / genetics*
  • Base Sequence
  • China
  • DNA Mutational Analysis
  • Female
  • High Mobility Group Proteins
  • Humans
  • Molecular Sequence Data
  • Polycystic Ovary Syndrome / genetics*
  • Polymorphism, Single Nucleotide / genetics
  • Receptors, Progesterone / genetics*
  • Sequence Deletion / genetics
  • Trans-Activators
  • Trinucleotide Repeats / genetics

Substances

  • Apoptosis Regulatory Proteins
  • High Mobility Group Proteins
  • Receptors, Progesterone
  • TOX3 protein, human
  • Trans-Activators