Prognostic value of long non-coding RNA HOTAIR in various cancers

Qiwen Deng; Huiling Sun; Bangshun He; Yuqin Pan; Tianyi Gao; Jie Chen; Houqun Ying; Xian Liu; Feng Wang; Yong Xu; Shukui Wang

doi:10.1371/journal.pone.0110059

Prognostic value of long non-coding RNA HOTAIR in various cancers

PLoS One. 2014 Oct 10;9(10):e110059. doi: 10.1371/journal.pone.0110059. eCollection 2014.

Authors

Qiwen Deng¹, Huiling Sun², Bangshun He¹, Yuqin Pan¹, Tianyi Gao³, Jie Chen², Houqun Ying⁴, Xian Liu¹, Feng Wang¹, Yong Xu¹, Shukui Wang¹

Affiliations

¹ Central Laboratory, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
² Department of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu, China.
³ Department of Clinical Laboratory, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
⁴ Medical college, Southeast University, Nanjing, Jiangsu, China.

Abstract

Long non-coding RNA has been involved in cancer progression, and high HOX transcript antisense intergenic RNA (HOTAIR) is thought to be a poor prognostic indicator in tumorigenesis of multiple types of cancer. Hence, the present study further reveals its prognostic value in tumor malignancy. A systematic review of PubMed and Web of Science was carried out to select literatures relevant to the correlation between HOTAIR expression levels and clinical outcome of various tumors. Overall survival (OS), metastasis-free survival (MFS), recurrence-free survival (RFS), and disease-free survival (DFS) were subsequently analyzed. Data from studies directly reporting a hazard ratio (HR) and the corresponding 95% confidence interval (CI) or a P value as well as survival curves were pooled in the current meta-analysis. A total of 2255 patients from 19 literatures almost published in 2011 or later were included in the analysis. The results suggest that HOTAIR was highly associated with HR for OS of 2.33 (95%CI = 1.77-3.09, Pheterogeneity = 0.016). Stratified analyses indicate that elevated levels of HOTAIR appears to be a powerful prognostic biomarker for patients with colorectal cancer (HR = 3.02, 95CI% = 1.84-4.95, Pheterogeneity = 0.699) and esophageal squamous cell carcinomas (HR = 2.24, 95CI% = 1.67-3.01, Pheterogeneity = 0.711), a similar effect was also observed in analysis method and specimen, except for ethnicity. In addition, Hazard ratios for up-regulation of HOTAIR for MFS, RFS, and DFS were 2.32 (P<0.001), 1.98 (P = 0.369), and 3.29 (P = 0.001), respectively. In summary, the high level of HOTAIR is intimately associated with an adverse OS in numerous cancers, suggesting that HOTAIR may act as a potential biomarker for the development of malignancies.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review

MeSH terms

Gene Expression Regulation, Neoplastic
Humans
Neoplasms / genetics*
Neoplasms / mortality
Neoplasms / pathology
Odds Ratio
Prognosis
RNA, Long Noncoding / genetics*
Survival Analysis

Substances

HOTAIR long untranslated RNA, human
RNA, Long Noncoding

Grants and funding

This project was supported by grants from The National Nature Science Foundation of China (no. 81172141, 81200401), Nanjing Science and Technology Committee Project (no. 201108025), Nanjing Medical Technology Development Project (no. ZKX11025), Nanjing Health Young Talent Project, Jiangsu Provincial Key Medical Talents to S.K.W., and Nanjing Medical Science and Technique Development Foundation to Y.Q.P. (no. QRX11255) and B.S.H. (no. QRX11254). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.