CEA a thrombus CAM: CEACAM2, a twin of CEACAM1?

Blood. 2014 Oct 9;124(15):2323-4. doi: 10.1182/blood-2014-08-594101.

Abstract

In this issue of Blood, Alshahrani et al demonstrate that carcinoembryonic antigen-related cell adhesion molecule 2 (CEACAM2) is expressed on platelets and negatively regulates the collagen receptor glycoprotein (GP)VI-FcRγ chain and C-type lectin-like receptor 2 (CLEC-2)-mediated platelet activation.

Publication types

  • Comment

MeSH terms

  • Animals
  • Antigens, CD / metabolism*
  • Cell Adhesion Molecules / metabolism*
  • Lectins, C-Type / metabolism*
  • Platelet Membrane Glycoproteins / metabolism*
  • Signal Transduction*
  • Thrombosis / metabolism*
  • Thrombosis / pathology*

Substances

  • Antigens, CD
  • CD66 antigens
  • CLEC-2 protein, mouse
  • Cell Adhesion Molecules
  • Lectins, C-Type
  • Platelet Membrane Glycoproteins
  • platelet membrane glycoprotein VI