Abstract
In this issue of Blood, Alshahrani et al demonstrate that carcinoembryonic antigen-related cell adhesion molecule 2 (CEACAM2) is expressed on platelets and negatively regulates the collagen receptor glycoprotein (GP)VI-FcRγ chain and C-type lectin-like receptor 2 (CLEC-2)-mediated platelet activation.
MeSH terms
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Animals
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Antigens, CD / metabolism*
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Cell Adhesion Molecules / metabolism*
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Lectins, C-Type / metabolism*
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Platelet Membrane Glycoproteins / metabolism*
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Signal Transduction*
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Thrombosis / metabolism*
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Thrombosis / pathology*
Substances
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Antigens, CD
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CD66 antigens
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CLEC-2 protein, mouse
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Cell Adhesion Molecules
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Lectins, C-Type
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Platelet Membrane Glycoproteins
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platelet membrane glycoprotein VI