Auditory symptoms as an unrecognized manifestation of opioid toxicity: two case reports

J Pain Palliat Care Pharmacother. 2014 Dec;28(4):378-81. doi: 10.3109/15360288.2014.959233. Epub 2014 Oct 9.

Abstract

Neuropsychiatric and gastrointestinal side effects of opioids are well documented, but self-reported hearing disturbance from opioids is often unrecognized. Two cases are presented illustrating a possible association between auditory symptoms and opioid toxicity. Possible mechanisms are discussed.

Keywords: auditory symptoms; hearing disturbance; opioid; toxicity.

Publication types

  • Case Reports

MeSH terms

  • Administration, Oral
  • Aged
  • Analgesics, Opioid / administration & dosage
  • Analgesics, Opioid / adverse effects*
  • Delayed-Action Preparations / adverse effects
  • Female
  • Hearing Disorders / chemically induced*
  • Humans
  • Hydromorphone / administration & dosage
  • Hydromorphone / adverse effects*
  • Infusions, Subcutaneous / adverse effects
  • Middle Aged

Substances

  • Analgesics, Opioid
  • Delayed-Action Preparations
  • Hydromorphone