Synthesis and 5HT-receptors affinity of some 4-phenylquinoline derivatives

M Anzini; S Vomero; A Garofalo; A Cappelli; A Cagnotto

Synthesis and 5HT-receptors affinity of some 4-phenylquinoline derivatives

Farmaco. 1989 Jun;44(6):555-63.

Authors

M Anzini¹, S Vomero, A Garofalo, A Cappelli, A Cagnotto

Affiliation

¹ Dipartimento Farmaco Chimico Tecnologico, Università di Siena, Italy.

PMID: 2529861

Abstract

The synthesis of a series of 4-phenylquinolines with substituents in 2,3 and 6-position of the quinoline nucleus is described. Serotoninergic activity towards 5HT1A, 5HT1B, 5HT2, 5HT1A + B receptors and the 5-HT-uptake site was also studied.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Brain / metabolism
Chemical Phenomena
Chemistry
In Vitro Techniques
Magnetic Resonance Spectroscopy
Male
Paroxetine
Piperidines
Quinolines / chemical synthesis*
Quipazine / analogs & derivatives
Quipazine / chemical synthesis*
Quipazine / metabolism
Rats
Receptors, Serotonin / metabolism*
Serotonin Antagonists
Synapses / metabolism

Substances

Piperidines
Quinolines
Receptors, Serotonin
Serotonin Antagonists
Paroxetine
Quipazine