Abstract
Periprosthetic infection remains a challenging clinical complication. We investigated the antibacterial properties of pure (99.9%) magnesium (Mg) in vitro and in an in vivo rat model of implant-related infection. Mg was highly effective against methicillin-resistant Staphylococcus aureus-induced osteomyelitis and improved new peri-implant bone formation. Bacterial icaA and agr RNAIII transcription levels were also assessed to characterize the mechanism underlying the antibacterial properties of the Mg implant.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / pharmacology*
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Biofilms / drug effects
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Biofilms / growth & development
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Bone Density / drug effects
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Bone Plates / microbiology
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Bone Screws / microbiology
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Disease Models, Animal
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Femur / drug effects
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Femur / microbiology
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Femur / surgery
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Magnesium / pharmacology*
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Methicillin-Resistant Staphylococcus aureus / drug effects*
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Methicillin-Resistant Staphylococcus aureus / growth & development
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Microbial Sensitivity Tests
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Osteomyelitis / drug therapy*
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Osteomyelitis / microbiology
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Osteomyelitis / surgery
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Prosthesis-Related Infections / drug therapy*
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Prosthesis-Related Infections / microbiology
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Prosthesis-Related Infections / surgery
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Rats
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Rats, Sprague-Dawley
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Staphylococcal Infections / drug therapy*
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Staphylococcal Infections / microbiology
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Staphylococcal Infections / surgery
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Titanium / pharmacology
Substances
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Anti-Bacterial Agents
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Titanium
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Magnesium