Antibacterial properties of magnesium in vitro and in an in vivo model of implant-associated methicillin-resistant Staphylococcus aureus infection

Antimicrob Agents Chemother. 2014 Dec;58(12):7586-91. doi: 10.1128/AAC.03936-14. Epub 2014 Oct 6.

Abstract

Periprosthetic infection remains a challenging clinical complication. We investigated the antibacterial properties of pure (99.9%) magnesium (Mg) in vitro and in an in vivo rat model of implant-related infection. Mg was highly effective against methicillin-resistant Staphylococcus aureus-induced osteomyelitis and improved new peri-implant bone formation. Bacterial icaA and agr RNAIII transcription levels were also assessed to characterize the mechanism underlying the antibacterial properties of the Mg implant.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / pharmacology*
  • Biofilms / drug effects
  • Biofilms / growth & development
  • Bone Density / drug effects
  • Bone Plates / microbiology
  • Bone Screws / microbiology
  • Disease Models, Animal
  • Femur / drug effects
  • Femur / microbiology
  • Femur / surgery
  • Magnesium / pharmacology*
  • Methicillin-Resistant Staphylococcus aureus / drug effects*
  • Methicillin-Resistant Staphylococcus aureus / growth & development
  • Microbial Sensitivity Tests
  • Osteomyelitis / drug therapy*
  • Osteomyelitis / microbiology
  • Osteomyelitis / surgery
  • Prosthesis-Related Infections / drug therapy*
  • Prosthesis-Related Infections / microbiology
  • Prosthesis-Related Infections / surgery
  • Rats
  • Rats, Sprague-Dawley
  • Staphylococcal Infections / drug therapy*
  • Staphylococcal Infections / microbiology
  • Staphylococcal Infections / surgery
  • Titanium / pharmacology

Substances

  • Anti-Bacterial Agents
  • Titanium
  • Magnesium